IGF-1 DES(1,3) – Research-Grade Truncated IGF-1 Analog

IGF-1 DES(1,3) is a synthetic truncated analog of insulin-like growth factor 1 in which the first three N-terminal residues (Gly-Pro-Glu) are removed, yielding a 67-amino-acid variant. This N-terminal deletion markedly reduces binding affinity for IGF-binding proteins, separating IGF-1 DES(1,3) structurally and functionally from native IGF-1 and from extended analogs such as IGF-1 LR3, and in laboratory research settings it is utilized as a reference material for studying IGFBP interaction models, receptor-binding kinetics, and structure–activity relationships within the growth factor peptide class. Owing to its defined truncation and reduced carrier-protein association, IGF-1 DES(1,3) exhibits physicochemical properties that allow researchers to examine peptide stability, free-versus-bound fraction behavior, and putative regulatory activity in vitro without reliance on full-length native growth factor proteins.

Its reproducible synthetic profile supports controlled use in mechanistic assays, comparative analog studies against LR3 and wild-type sequences, and exploratory biochemical research conducted under controlled laboratory conditions. This material is intended strictly for laboratory research use only and is not designed for human or veterinary application.

Related research compounds

Follistatin 344 · ACE-031 · CJC-1295 (No DAC) · Ipamorelin · Sermorelin · HGH Frag 176-191

Documentation and methods

Analytical testing · How to read a COA · Batch COAs · Storage and handling · What are research peptides

Important Information About This Research Product

1. 1 Your vials are not empty. The lyophilized material may collect at the bottom of the vial and can appear minimal prior to inspection.
2. 2 All products are supplied as lyophilized (freeze-dried) powder and require reconstitution. Bacteriostatic water is not supplied.
3. 3 Store in a dry, cool, and dark environment away from UV exposure. For optimal preservation, storage at approximately 4°C is recommended.
4. 4 This material is strictly for laboratory and research use only. No instructions regarding reconstitution, dosing, or administration can be provided.